Search results for "mtDNS variācijas"

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Ar novecošanos saistītu biomarķieru un mtDNS mutāciju izpēte multirezistentās tuberkulozes pacientiem

2020

Darba mērķis: izmantojot biomarķierus, noteikt iespējamo multirezistentās tuberkulozes (MDR-TB) infekcijas saistību ar imūnsistēmas novecošanos un noskaidrot mtDNS variāciju lomu slimības gaitā un farmakoterapijā. Darbā ir analizētas mtDNS daudzuma un telomēru garuma izmaiņas, un apskatīta MDR-TB pacientu ieradumu un citu saistīto faktoru ietekme. MDR-TB pacientiem konstatēts paaugstināts mtDNS kopiju skaits un samazināts telomēru garums salīdzinājumā ar kontroles grupu. Būtiskās izmaiņas vērojamas tikai vīriešu grupā. Biomarķieru izmaiņas iespaidoja arī smēķēšana, terapijas ilgums un saņemto zāļu devu skaits. Identificētas vairākas mtDNS variācijas ar iespējamo ietekmi uz slimības procesie…

telomēru garumsrelatīvais mtDNS daudzumsMDR-TBBioloģijamtDNS variācijasimunosenescence

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PEPhysical Sciences and Engineering
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LSLife Sciences
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